Yinxiong Li

Principal Investigator
Biomedicine and health
GUANGZHOU INSTITUTES OF BIOMEDICINE AND HEALTH
China

Scientist Molecular Biology
Biography

Dr. Yinxiong Li received his B. Sc. and Ph.D. from Hunan Medical College and Peking Union Medical College in 1985 and in 1991. With NIH Fogarty Award, Dr. Li had his postdoctoral fellowship training in Vanderbilt University Medical Center and Medical College of Georgia from 1992-2000. He was assistant professor since 2000 in Duke University Medical Center for ten years, leading a group working on many NIH founded projects including heart and liver development, alcohol induced birth defects, tissue repair and regeneration, particular emphasis the role of Hedgehog signaling on stem cell differentiation and liver fibrosis. Dr. Li severedfor two NIH Scientific Study Sections and one AHA study section, Currently sever as regular scientific reviewer of four Journals including Gastroenterology, Proteomics Hepatologyand Cell Regeneration.

Research Intrest

Major Goal: Explore to lead a team conducting stem cell biology research and establishing human liver stem cell bank for replacing liver whole organ transplantation in clinic practice. Research projects: · Molecular basis of liver development and in vitro stem cell hepatic differentiation · Teratogenic role of alcohol-induced birth defects · Adult liver stem cell, tissue repair and liver regeneration · Cholesterol and metabolites level associate Hh signaling and stem cell function · Disease biomarker screening and molecular diagnosis.

List of Publications
Wilkbanks AM, Fralish GB, Kirby ML, Barak LS, Li Y-X et al. (2004) Arrestin 2 regulates zebrafish development through the sonic hedgehog pathway. Science. 306: 2264-2267.
Li Y-X, Kirby ML (2003) Coordinated and conserved expression of alphoid repeat and alphoid repeat-tagged coding sequences. Developmental Dynamics. 228: 72-81.
Li Y-X, Zdanowicz M, Young L, Kumiski D, Leatherbury L et al.(2003) Cardiac neural crest in zebrafish embryos contributes to myocardial cell lineage and early heart function. Development Dynamics. 226: 540-550.