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Experts in Bioinformatics and Systems Biology
Takeshi Kikuchi Neeraj Wadhwa Hui-Hsien Chou Lynn Adler Paltu Kumar Dhal Stein Aerts Kamal Rawal Abhishek Mitra NGAI Sai Ming Robert Sablowski Murodzhon Akhmedov Luciano Cascione Ivo Kwee MARISSA AMBIO Alberto Arribas Carmena Dr. Rajeev K. Tyagi TRUNG DAC NGUYEN Elizabeth A. Connor Gouher Ahmed Ramana Gosukonda View MoreBiography
Drp1 is a dynamin GTPase important for mitochondrial and peroxisomal division. Drp1 oligomerization and mitochondrial recruitment are regulated by multiple factors, including interaction with mitochondrial receptors such as Mff, MiD49, MiD51 and Fis. In addition, both endoplasmic reticulum (ER) and actin filaments play positive roles in mitochondrial division, but mechanisms for their roles are poorly defined.
Research Intrest
oligomers assemble on ER, from which they can transfer to mitochondria. Suppression of Mff or inhibition of actin polymerization through the formin INF2 significantly reduces all Drp1 oligomer populations (mitochondrial, peroxisomal,