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Shyam K. Sharan

Mouse Cancer Genetics Program
The Center for Cancer Research
United States of America

Scientist Genetics
Biography

Dr. Sharan obtained his B.Sc. in botany and M.Sc. in genetics from Delhi University, Delhi. In 1994, he obtained his Ph.D. in genetics under Dr. Terry Magnuson at Case Western Reserve University. He then joined Dr. Allan Bradley's laboratory at Baylor College of Medicine as a Howard Hughes Medical Institute Associate. In 1998, Dr. Sharan established the Genetics of Cancer Susceptibility Group in the ABL-Basic Research Program. His group is involved in the functional analysis of tumor suppressor genes in mice. In 1999, Dr. Sharan joined the Center for Cancer Research, NCI. In 2008, Dr. Sharan received the NCI Director's Intramural Innovation Award and in 2009 he received the NIH merit award and the Arthur Flemming Award for his work on functional analysis of BRCA1 and BRCA2. Dr. Sharan is also the Scientific Director of the Center for Advanced Preclinical Research (CAPR). 

Research Intrest

Cancer Biology, Genetics and Genomics 

List of Publications
Kuznetsov SG, Liu P, Sharan SK (2008) Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2. Nat. Med. 14: 875-81.
Chang S, Wang RH, Akagi K, Kim KA, Martin BK, et al. (2011) Tumor suppressor BRCA1 epigenetically controls oncogenic microRNA-155. Nat. Med. 17: 1275-82.
Thirthagiri E, Klarmann KD, Shukla AK, Southon E, Biswas K, et al. (2016) BRCA2 minor transcript lacking exons 4-7 supports viability in mice and may account for survival of humans with a pathogenic biallelic mutation. Hum Mol Genet. 25:1934-1945.
Hartford SA, Chittela R, Ding X, Vyas A, Martin B, et al. (2016) Interaction with PALB2 Is Essential for Maintenance of Genomic Integrity by BRCA2. PLoS Genet. 12:e1006236.
Ding X, Ray Chaudhuri A, Callen E, Pang Y, Biswas K, et al. (2016) Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies. Nat Commun. 7:12425. doi: 10.1038/ncomms12425.
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