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Shuo Gu

RNA Biology Laboratory
The Center for Cancer Research
United States of America

Scientist Genetics
Biography

Shuo Gu received his B.A. in Tsinghua University, CHINA in 1998. He completed his Ph.D. training in the laboratory of Dr. John Rossi at Beckman Research Institute, City of Hope, Los Angeles. Shuo Gu undertook his postdoctoral training in the laboratory of Dr. Mark Kay at Stanford University Medical School, Palo Alto. Both his Ph.D. and postdoctoral research focused on the mechanisms of RNA interference and microRNA pathways, and their applications in gene therapy. He Joined the Gene Regulation and Chromosome Biology Laboratory in 2013. 

Research Intrest

Cancer Biology, Chromosome Biology, Genetics and Genomics, Molecular Biology and Biochemistry 

List of Publications
Gu S, Jin L, Huang Y, Zhang F, Kay MA (2012) Slicing-independent RISC activation requires the argonaute PAZ domain. Curr Biol. 22: 1536-1542.
Gu S, Jin L, Zhang Y, Huang Y, Zhang F, et al. (2012) The loop position of shRNAs and pre-miRNAs is critical for the accuracy of dicer processing in vivo. Cell 151: 900-111.
Bofill-De Ros X, Gu S (2016) Guidelines for the optimal design of miRNA-based shRNAs. Methods103: Epub 157-166.
Dai L, Chen K, Youngren B, Kulina J, Yang A, et al. (2016 ) Cytoplasmic Drosha activity generated by alternative splicing. Nucleic Acids Res 44: Epub 10454-10466.
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