Dr Santosh developed and use models based on quantum mechanics and statistical physics to investigate various exciting equilibrium and non-equilibrium properties with a special focus on the mechanical and transport properties. His major goals in science research are to bridge the gap between time/length scales underlying different computational methods and thereby contribute extensively to the current understanding of various phenomena in physics and materials science.

His research interests are broadly aimed at a fundamental understanding of the various condensed/soft matter systems with an interface to applied science. He to use a combination of quantum/statistical physics and multiscale simulation methods including first principle calculations, molecular dynamics (quantum/atomistic/coarse-grained) and Monte Carlo simulations.