Ronan Le Lagadec

Researcher
Department of Inorganic Chemistry
National Autonomous University of Mexico
Mexico

Scientist Chemistry
Biography

Dr. Le Lagadec obtained his PhD in Organometallic Chemistry (Ruthenium chemistry) under the supervision of Prof. P. H. Dixneuf at the University of Rennes I (France). Between 1994 and 1996, he held a postdoctoral position at the National Institute for Materials and Chemistry Research, Tsukuba (Japan), within the group of Prof. M. Tanaka, working on the catalytic synthesis of polysilanes. He joined the Institute of Chemistry on 1996, and since 1998 he is Full Researcher.

Research Intrest

Dr. Le Lagadec research activities are focused on the synthesis and the use of group 8 metals (Fe, Ru, Os) cyclometalated complexes, and they are particularly interested in their interactions with redox-active enzymes, with applications in bio-sensing and in medicine (anticancer activity for instance). Analytical tools such as electrochemistry, UV-vis spectroscopy, and dissolved oxygen concentration measurement are commonly used for such studies. On the other hand, thier organometallic complexes have been used as very efficient catalysts for living / controlled radical polymerization (ATRP process). Finally, they are also interested in the synthesis of bimetallic, pincer-type, complexes displaying axial chirality.

List of Publications
Bautista HR, Díaz RO, Shen LQ, Orvain C, Gaiddon C, Le Lagadec R, Ryabov AD. Impact of cyclometalated ruthenium (II) complexes on lactate dehydrogenase activity and cytotoxicity in gastric and colon cancer cells. Journal of inorganic biochemistry. 2016 Oct 31;163:28-38.
Estrada‐Montaño AS, Ryabov AD, Gries A, Gaiddon C, Le Lagadec R. Iron (III) Pincer Complexes as a Strategy for Anticancer Studies. European Journal of Inorganic Chemistry. 2017 Mar 27;2017(12):1673-8.
Espinosa-Jalapa NA, Ramires MA, Toscano RA, Djukic JP, Le Lagadec R. Preparative resolution of stable enantio-enriched POCOP-based planar chiral pincer complexes. Journal of Organometallic Chemistry. 2017 Apr 12.

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