Rafael Casellas

Laboratory of Cancer Biology and Genetics
The Center for Cancer Research
United States of America

Scientist Genetics
Biography

Dr. Rafael Casellas received his Ph.D. in Molecular Immunology from the Rockefeller University in 2002. There, he worked under Dr. Michel Nussenzweig to study the role of immunoglobulin gene expression and recombination in the establishment of B cell tolerance and peripheral activation. From 2002 to 2003 he did postdoctoral training with David Baltimore at the California Institute of Technology, where he continued his studies of B cell activation. In December 2003, Dr. Casellas moved to the Laboratory of Molecular Immunogenetics of NIAMS to create the Genomics & Immunity Group, where he is currently a senior investigator and branch chief. Dr. Casellas is also serving as an adjunct investigator at the Center for Cancer Research, NCI. 

Research Intrest

Genetics and Genomics, Immunology 

List of Publications
Kouzine, F., D. Wojtowicz, A. Yamane, W. Resch, K.-R. Kieffer-Kwon, et al. (2013) Global regulation of promoter melting in naïve lymphocytes. Cell. 153: 988-999.
Kieffer-Kwon KR, Tang E, Mathe J, Qian MH, Sung, et al. (2013) Interactome maps of mouse gene regulatory domains reveal basic principles of transcriptional regulation. Cell. 155: 1507-1520.
Meng FL, Du Z, Federation A, Hu J, Wang Q, et al. (2014) Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability. Cell. 159: 1538-1548.
Qian J, Wang Q, Dose M, Pruett N, Kieffer-Kwon K-R et al. (2014) Casellas B cell super-enhancers and regulatory clusters recruit AID tumorigenic activity. Cell. 159: 1524-1537.