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Paul S. Meltzer

Head, Molecular Genetics Section
The Center for Cancer Research
United States of America

Scientist Genetics
Biography

Dr. Meltzer is a leader in the application of genome science to cancer research. His recent studies investigate the genetic and epigenetic basis of cancers in adult and pediatric patients, particularly those with bone and soft tissue sarcomas. Dr. Meltzer's long-term goal is to improve diagnosis and therapy through better understanding of the mechanisms driving tumor growth. As Branch Chief, Dr. Meltzer oversees a program focused on the mechanisms and consequences of genome instability, non-coding RNA biology, and translational genomics. Developing applications of genome technologies for the oncology clinic is an important priority within the Branch. 

Research Intrest

Chromosome Biology, Computational Biology, Genetics and Genomics, Molecular Biology and Biochemistry, Systems Biology 

List of Publications
Ellis RJ, Wang Y, Stevenson HS, Boufraqech M, Patel D, et al. (2014) Genome-wide methylation patterns in papillary thyroid cancer are distinct based on histological subtype and tumor genotype. J. Clin. Endocrinol. Metab. 99: E329-37.
Gao R, Das BB, Chatterjee R, Abaan OD, Agama K, et al. (2014) Epigenetic and genetic inactivation of tyrosyl-DNA-phosphodiesterase 1 (TDP1) in human lung cancer cells from the NCI-60 panel. DNA Repair (Amst.). 13: 41648.
Li XL, Hara T, Choi Y, Subramanian M, Francis P, et al. (2014) A p21-ZEB1 complex inhibits epithelial-mesenchymal transition through the microRNA 183-96-182 cluster. Mol. Cell. Biol. 34: 533-50.
Subramanian M, Francis P, Bilke S, Li XL, Hara T, et al. (2015) A mutant p53/let-7i-axis-regulated gene network drives cell migration, invasion and metastasis. Oncogene. 34: 1094-104.
Gindin Y, Valenzuela MS, Aladjem MI, Meltzer PS, Bilke S (2014) A chromatin structure-based model accurately predicts DNA replication timing in human cells. Mol. Syst. Biol. 10: 722.
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