Okihide Hikosaka

NIH Distinguished Investigator
Neuronal Networks Sectio
National Eye Institute
United States of America

Scientist Ophthalmology
Biography

r. Hikosaka received his M.D. and Ph.D. from University of Tokyo where he worked in the laboratory of Hiroshi Shimazu on the brainstem vestibulo-oculomotor system. He did postdoctoral research with Robert Wurtz at the Laboratory of Sensorimotor Research, NEI on the role of the substantia nigra pars reticulata in the control of saccadic eye movements. He became Assistant Professor at Toho University School of Medicine (Tokyo) in 1979, Full Professor at National Institute of Physiological Sciences (Okazaki) in 1988, and Full Professor at Juntendo University School of Medicine (Tokyo) in 1993. In 2002, he returned to the Laboratory of Sensorimotor Research, NEI as a Senior Investigator and Chief of the Section of Neuronal Networks. He was elected to the American Academy of Arts & Sciences in 2011. His main interest is the neural mechanisms of voluntary behavior. His laboratory studies the mechanisms of motivation, learning, skill, decision-making, attention, and oculomotor control.

Research Intrest

Control of eye movements, Functions of the basal ganglia, Neural mechanisms of motivation, Neural mechanisms of procedural learning and Mechanisms of spatial attention.

List of Publications
Kim HF, Hikosaka O. Distinct basal ganglia circuits controlling behaviors guided by flexible and stable values. Neuron. 2013 Sep 4;79(5):1001-10.
Kim HF, Ghazizadeh A, Hikosaka O. Dopamine neurons encoding long-term memory of object value for habitual behavior. Cell. 2015 Nov 19;163(5):1165-75.
Kim HF, Amita H, Hikosaka O. Indirect Pathway of Caudal Basal Ganglia for Rejection of Valueless Visual Objects. Neuron. 2017 May 17;94(4):920-30.