Manuel B. Datiles III, M.D. is a medical officer and senior clinical investigator for the National Eye Institute (NEI), National Institutes of Health (NIH). Dr. Datiles graduated cum laude with a bachelor’s degree and M.D. from the University of Santo Tomas in Manila, Philippines. In 1979, Dr. Datiles finished his ophthalmology residency and became an NEI employee where he completed his basic and clinical cornea and cataract research fellowships. Dr. Datiles completed his corneal and cataract surgical fellowship at the Wilmer Eye Institute at Johns Hopkins University. In 1983, Dr. Datiles became a primary cornea and cataract clinical research principal investigator. Dr. Datiles is recognized around the world for his expertise in cataract detection, measurement and monitoring, as well as the development and testing of anti-cataract drugs. Due to his expertise he is the section editor for Duane’s Clinical Ophthalmology textbook series, a primary learning resource for ophthalmologist. Also, Dr. Datiles serves as an ad hoc editorial board member and reviewer for the major ophthalmic journals. Currently, Dr. Datiles consults eye patients from various clinics within NIH, such as adult stem cell transplant patients with ocular graft versus host disease. Dr. Datiles and Walter Stark, M.D., director of the Cataract and Corneal Disease Program, are conducting clinical research at the NEI Clinical Center about the pathogenesis and development of cataracts. In addition, they are performing clinical trials related to anti-cataract drugs at the Wilmer Eye Institute at Johns Hopkins University. Dr. Datiles in collaboration with J. Fielding Hejtmancik, M.D., Ph.D. of NEI are conducting research concerning cataract genetics. Also, Dr. Datiles in collaboration with J. Samuel Zigler Jr., Ph.D. of Johns Hopkins University Hospital are performing research on lens protein aggregation studies. In addition to his research, Dr. Datiles and Rafat Ansari, Ph.D. of NASA-John Glenn Research Center in Cleveland, OH co-developed a clinical dynamic light scattering device that detects pre-cataract lens protein changes caused by oxidative stress. Please follow the link for more information about the NASA research.

Cataract development, prevention, treatment Lens imaging/monitoring systems, implantation Diabetic cataracts and corneal disorders Ocular graft versus host disease in stem cell transplants Corneal wound healing, transparency, transplantation Anterior eye segment disorders