Jon Lorsch

Director
Biophysics and Biophysical Chemistry
National Institute of General Medical Sciences
United States of America

Scientist Chemistry
Biography

Jon R. Lorsch received a B.A. in chemistry from Swarthmore College in 1990 and a Ph.D. in biochemistry from Harvard University in 1995, where he worked in the laboratory of Jack Szostak, Ph.D. He conducted postdoctoral research at Stanford University in the laboratory of Daniel Herschlag, Ph.D. Jon R. Lorsch, Ph.D., became the director of the National Institute of General Medical Sciences (NIGMS) in August 2013. In this position, Lorsch oversees the Institute's $2.5 billion budget, which supports basic research that increases understanding of biological processes and lays the foundation for advances in disease diagnosis, treatment and prevention. NIGMS supports more than 3,000 investigators and 4,500 research grants–over 11 percent of the total number of research grants funded by NIH as a whole. Additionally, NIGMS supports approximately 26.3 percent of the NRSA trainees who receive assistance from NIH.

Research Intrest

RNA Biology, viral infection, neurodegenerative diseases and cancer.

List of Publications
Dong J, Aitken CE, Thakur A, Shin BS, Lorsch JR, Hinnebusch AG. Rps3/uS3 promotes mRNA binding at the 40S ribosome entry channel and stabilizes preinitiation complexes at start codons. Proceedings of the National Academy of Sciences. 2017 Feb 21:201620569.
Monika M. Mutational analysis of eukaryotic initiation factor 5 eIF5 to determine its residues for their role to maintain the accuracy of start codon AUG recognition.
Aitken CE, Beznosková P, Vlčkova V, Chiu WL, Zhou F, Valášek LS, Hinnebusch AG, Lorsch JR. Eukaryotic translation initiation factor 3 plays distinct roles at the mRNA entry and exit channels of the ribosomal preinitiation complex. Elife. 2016 Oct 26;5:e20934.

Global Scientific Words in Chemistry