Jeffrey Schlom

Laboratory of Tumor Immunology and Biology
The Center for Cancer Research
United States of America

Scientist Immunology
Biography

Dr. Jeffrey Schlom is Chief of the Laboratory of Tumor Immunology and Biology, Center for Cancer Research, National Cancer Institute, NIH. He received his B.S. from the Ohio State University, M.S. from Adelphi University, and Ph.D. from the Waksman Institute at Rutgers University. Dr. Schlom directs a translational research program in which the latest advances in immunology and immunotherapy are used to design and develop a range of potential novel immunotherapeutic approaches for a variety of human cancers. His most recent work involves the development of novel therapeutic cancer vaccines, checkpoint inhibitors and immune modulators, both as a monotherapy and in combination therapies. The program focuses on the design and development of novel "off the shelf" immunotherapeutics that can be translated from hypothesis-driven preclinical studies to science-based clinical studies both at the NIH and at numerous Cancer Centers throughout the U.S. Dr. Schlom serves on the editorial boards of numerous scientific journals. He has authored more than 700 scientific publications and holds numerous patents for monoclonal antibody and recombinant vaccine generation and uses. 

Research Intrest

Cancer Biology, Clinical Research, Immunology, Stem Cell Biology 

List of Publications
Kim PS, Kwilas AR, Xu W, Alter S, Jeng EK, et al. ( 2016) IL-15 Superagonist/IL-15RαSushi-Fc Fusion Complex (IL-15SA/IL-15RαSu-Fc; ALT-803) Markedly Enhances Specific Subpopulations of NK and Memory CD8+ T cells, and Mediates Potent anti-tumor Activity Against Murine Breast and Colon Carcinomas. Oncotarget. 7: 16130-45.
Vandeveer AJ, Fallon JK, Tighe R, Sabzevari H, Schlom J, et al. (2016) Systemic Immunotherapy of Non-Muscle Invasive Mouse Bladder Cancer with Avelumab, an Anti-PD-L1 Immune Checkpoint Inhibitor. Cancer Immunol Res. 4: 452-62.
Farsaci B, Donahue RN, Grenga I, Lepone LM, Kim PS, et al. (2016) Analyses of Pretherapy Peripheral Immunoscore and Response to Vaccine Therapy. Cancer Immunol Res. 4: 755-65.
Jochems C, Hodge JW, Fantini M, Fujii R, Morillon YM 2nd, et al. (2016) Cell Line (haNK) Expressing High Levels of Granzyme and Engineered to Express the High Affinity CD16 Allele. Oncotarget. 7: 86359-73.
Fallon JK, Vandeveer AJ, Schlom J, Greiner JW (2017) Enhanced Antitumor Effects by Combining an IL-12/anti-DNA Fusion Protein with Avelumab, an anti-PD-L1 Antibody. Oncotarget. 8: 20558-20571.