Frank J. Gonzalez

Laboratory of Metabolism
The Center for Cancer Research
United States of America

Scientist Molecular Biology
Biography

Dr. Gonzalez received his Ph.D. from the University of Wisconsin in Madison and was a staff fellow at the National Institute of Child Health and Human Development prior to joining the NCI. He received the Rawls Palmer Progress in Medicine Award from the American Society for Clinical Pharmacology, the John J. Abel Award and the Bernard B. Brodie Award in Drug Metabolism from the American Society of Pharmacology and Experimental Therapeutics, the George Scott Award from the Toxicology Forum, the North American Achievement Award from the International Society for the Study of Xenobiotics, the Elizabeth and James Miller Award in Experimental Oncology and an honorary D.Sc. from Mahidol University, Thailand. Dr. Gonzalez is an honorary member of the Society of Toxicology and an honorary fellow of the Royal College of Physicians of Thailand. He is a 14-time recipient of the Federal Technology Transfer Award and has three NIH Merit Awards. He is the co-inventor of 18 patents. His studies are largely focused on the role of cytochromes P450 and xenobiotic receptors in drug metabolism and chemical carcinogenesis. 

Research Intrest

Chemical Biology, Molecular Biology and Biochemistry 

List of Publications
Manna SK, Tanaka N, Krausz KW Haznadar M, Xue X, et al. (2014) Biomarkers of coordinate metabolic reprogramming in colorectal tumors in mice and humans. Gastroenterology. 46: 1313-1324.
C Jiang, C Xie, F Li, L Zhang, RG Nichols, et al. (2015) Gonzalez Intestinal farnesoid X receptor signaling promotes non-alcoholic fatty liver disease. J Clin. Invest 125: 386-402.
Jiang C, Xie C, Lv Y, Li J, Krausz KW, et al. (2015) Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction. Nature Commun 6: 10166.
Li F, Jiang C, Krausz KW, Li Y, Albert I, et al. (2013) Microbiome remodeling leads to inhibition of intestinal farnesoid X receptor signaling and decreased obesity. Nat Commun 4: 2384.