Ettore Appella

Laboratory of Cell Biology
The Center for Cancer Research
United States of America

Scientist Molecular Biology
Biography

Dr. Appella obtained his M.D. from the University of Rome, Italy, and continued his research at Johns Hopkins and the NIH (National Institute of Diabetes and Digestive and Kidney Diseases) on dehydrogenases. Since 1965, he has been in the Laboratory of Cell Biology where he continues his research on tumor immunology, the p53 tumor suppressor protein, and the design of antiviral drugs against HIV. 

Research Intrest

Cell Biology, Molecular Biology and Biochemistry, Virology 

List of Publications
Coussens NP, Hayashi R, Brown PH, Balagopalan L, Samelson LE (2014) Multipoint binding of the SLP-76 SH2 domain to ADAP is Critical for Oligomerization of SLP-76 Signaling Complexes in Stimulated T cells. Mol. Cell. Biol. 33: 4140-4151
Dudgeon C, Shreeram S, Tanoue K, Mazur SJ, Sayadi A, Robinson RC, Appella E, Bulavin DV (2013) Genetic variants and mutations of PPM1D control the response to DNA damage. Cell Cycle. 12: 2656-2664
Sakai H, Fujigaki H, Mazur SJ, Appella E (2014) Wild-type p53-induced phosphatase 1 (Wip1) forestalls cellular premature senescence at physiological oxygen levels by regulating DNA damage response signaling during DNA replication. Cell Cycle. 13: 1015-1029