First name / Surname: Duccio Cavalieri Address: Via Madonna del Piano 6, 50019 Sesto Fiorentino, Florence, Italy E-mail: [email protected] Website: www.duccioknights.org , Nationality: Italian Date of birth: 30.12.1966 Place of birth: Florence, Italy Gender: Male Current Position: Associate Professor (SSD BIO / 19 General Microbiology) Department of Biology, University of Florence. Areas of Research: Microbiology, Molecular Ecology, Evolutionary Biology, Genetics and Molecular Biology, Bioinformatics, Systems Biology, Functional Genomics, Immunology. Education and training 1994- Degree in Biological Sciences (110/110 praise), MSc in Biological Sciences. University of Florence, Italy, Advisor Mario Polsinelli, Enrico Casalone, Claudai Barberio. Master thesis in Molecular Microbiology and Population Genetics. 15/9/1994 to 15/9/1995 -Tirocinante - University of Florence, Italy Examination of the profession of Biologist, Advisor Dr. Claudia Barberio (150/150) , Genetics and Microbiology 31/10 / 1994-4 / 05/1998 . PhD in Genetics and Molecular Biology. PhD School of Genetics University of Pavia Italy Advisor Prof. Alessandro Galizzi, Prof. Mario Polsinelli, Prof. Robert K. Mortimer, Skills Acquired: Functional Genomics and Molecular Biology. 08/07/1998 -09/06/1999: Postdoctoral Fellow, Consortium Catania Research, University of Catania, Catania, IT. Advisor Prof. Antonino Catara, skills acquired, Genetics and Molecular Biology , 01/07/1999 to 15/9/1999: Postdoctoral Fellow , University of Florence, Italy, Advisor Prof. Mario Polsinelli and Claudia Barberio, skills acquired, Genetics and Microbiology. 01/10/1999 -01/09/2001: Postdoctoral Fellow, Harvard University, Cambridge, MA, USA Advisors Daniel Hartl, Andrew Murray, Rich Losick, Faculty of Arts and Sciences, Organismic and Evolutionary Biology Department. Population Genetics, Evolutionary Biology, Systems Biology, Genomics and Bioinformatics. Previously held Academic Positions 2001-2004. Principal Investigator, Group Leader Yeast Comparative Genomics Group, Faculty Member, Harvard Genomics Fellow, Molecular and Cellular Biology Department, Center for Genomics Research, Bauer Labs (Harvard University USA) 03/09/2001 at 30/09/2004. 2003-2004. Assistant Professor (Researcher Not Certified SSD BIO / 19-Microbiology) Faculty of Parmacy, Department of Pre-clinical and Clinical Pharmacology M.Aiazzi Mancini.) 29/12 / 2003-01 / 11/2004. Research project: Yeast as a model to study mitochondrial disease, stress response and dietary modulation. 2002-2011. Teaching Activities and courses held at the Faculty of Biotechnology and Pharmacy as Adjunct Professor of Microbiology (Professor Aggregate), Florence University. 2002-2015. Assistant Professor, (Confirmed Researcher-SSD BIO / 19 General Microbiology) Department of Clinical and Preclinical Pharmacology 'M. Aiazzi Mancini '. 2012-2015. Department Head of Computational Biology, Group Leader, Comparative Genomics Unit. Edmund Mach Foundation, Research and Innovation Center, Food Quality Nutrition & Health Department, Via E. Mach 1, 38010 S. Michele all'Adige (TN), Italy. Scientific Interests Cavalieri has pioneered the application of genomics to population genetics and ecology, producing the first yeast microarrays on the east coast in 2009 while at Harvard. Cavalieri's main scientific focus is investigating the evolutionary biology of the fungal "holobiome", the complex network of symbiotic interactions linking fungi and hosts, including immune system regulation. In this perspective, Cavalieri's team has mastered the application of metagenomics and metabolomics to the analysis of community structure, gene content, and function of complex microbial communities in human populations. Cavalieri's research interests range from nutrigenomics, metagenomics, computational metagenomics and immunology to the study of molecular determinants of the interaction of fungi and immune system in health and disease. In order to understand the evolutionary forces driving the adaptation of fungi to the host, Cavalieri's lab is also investigating the evolutionary ecology of the ascomyceteS. cerevisiae and its wild sanctuaries, including social insects such as wasps, and the role of the fungal cell wall as immune-modulator. These research lines have also led to the development of new antifungals and discovery of molecules acting as master regulators of the cross talk between the microbe and its host, including immunostimulants and immunosuppressors. Pubblications International peer-reviewed (ISI-JCR) 100 Book Chapters, Popular Press, Patents 15 Publications in International Conference proceedings (ISSN journals) 45 Total 160 Knights' work ( orcid.org/0000-0001-6426-5719) Has over 4380 citations, with and H index of 31 (Google Scholar) that makes him one of the Top Italian Scientists (TIS) according to VIA Academy. Cavalieri is also Co-Inventor (45%) of a Patent (PCT 2014) from Fondazione Mach, on the Immunomodulatory Potential of Plant MiRNAs and Has Pending (25%) for Patent application with Unifi (Bicyclic peptidomimetics for use in the treatment of fungal infections). Cavalieri is also a member of the editorial board of BMC Bioinformatics and FEMS Yeast Microbiology, and served as a project and center evaluator for the CNR, the University of Padua, the French Agency for Research Evauation AERES, the British Agency of Research (BBSRC), and The Research Agency of Luxembourg.

Microbiology, Molecular Ecology, Evolutionary Biology, Genetics and Molecular Biology, Bioinformatics, Systems Biology, Functional Genomics, Immunology.