Dinah S. Singer

Experimental Immunology Branch
The Center for Cancer Research
United States of America

Scientist Immunology
Biography

Dr. Dinah Singer has served as the Director of the Division of Cancer Biology (DCB), National Cancer Institute (NCI), National Institutes of Health (NIH), since 1999, while simultaneously serving as Senior Investigator and Chief of the Molecular Regulation Section of the Experimental Immunology Branch, NCI. After receiving her B.S. from the Massachusetts Institute of Technology and her Ph.D. from Columbia University, Dr. Singer was a postdoctoral fellow in the Laboratory of Biochemistry, NCI, and a senior investigator in the Immunology Branch, NCI. She serves on a number of scientific and advisory boards, is a member of the American Association of Immunologists and the American Association of Cancer Researchers, and has served as a Senior Science Officer at the Howard Hughes Medical Institute. Her research interests are in the areas of regulation of transcription, gene expression and molecular immunology. Dr. Singer serves in leadership positions on a variety of trans-NIH scientific and administrative committees, including NIH Common Fund initiatives. She has trained a large number of post-doctoral fellows, post-baccalaureate students and high school students who have gone on to successful scientific careers. 

Research Intrest

Chromosome Biology, Immunology, Molecular Biology and Biochemistry 

List of Publications
Mu J, Tai X, Iyer SS, Weissman JD, Singer A, et al. (2014) Regulation of MHC class I expression by Foxp3 and its effect on regulatory T cell function. J. Immunol. 192: 2892-903.
Devaiah BN, Singer DS (2012) Cross-talk among RNA polymerase II kinases modulates C-terminal domain phosphorylation. J. Biol. Chem. 287: 38755-66.
Barbash ZS, Weissman JD, Campbell JA, Mu J, Singer DS (2013) Major histocompatibility complex class I core promoter elements are not essential for transcription in vivo. Mol. Cell. Biol. 33: 4395-407.
Gegonne A, Tai X, Zhang J, Wu G, Zhu J, et al. (2012) The general transcription factor TAF7 is essential for embryonic development but not essential for the survival or differentiation of mature T cells. Mol. Cell. Biol. 32: 1984-97.
Devaiah BN, Lewis BA, Cherman N, Hewitt MC, Albrecht BK, et al. ( 2012) BRD4 is an atypical kinase that phosphorylates Serine2 of the RNA Polymerase II carboxy-terminal domain. Proc. Natl. Acad. Sci. U.S.A. 109: 6927-32.