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Dennis M. Klinman

Cancer and Inflammation Program
The Center for Cancer Research
United States of America

Scientist Immunology
Biography

Dr. Klinman received his MD/PhD from the University of Pennsylvania, and completed his fellowship training in Rheumatology at the National Institute of Arthritis, NIH. He headed the Section of Viral Immunology at the Center for Biologics Evaluation and Research of the FDA before joining the Laboratory of Experimental Immunology of the National Cancer Institute as chief of the Immunoregulation Group. He has authored over 300 peer reviewed articles, received of the FDA's 'Outstanding Scientist of the Year' Award, the 'Outstanding Achievement Award In Biology' from the Washington Academy of Science, and 'Meritorious', 'Outstanding' and 'Distinguished' Service Medals from the Public Health Service, among other honors. 

Research Intrest

Cancer Biology, Clinical Research, Immunology, Microbiology and Infectious Diseases, Stem Cell Biology 

List of Publications
Shirota Y, Shirota H, Klinman DM (2012) Intratumoral injection of CpG oligonucleotides induces the differentiation and reduces the immunosuppressive activity of myeloid-derived suppressor cells. J Immunol. 188: 1592.
Verthelyi D, Ishii KJ, Gursel M, Klinman DM (2001) Human peripheral blood cells differentially recognize and respond to two distinct CpG motifs. J Immunol. 166: 2372.
Klinman DM, Yi A, Beaucage SL, Conover J, Krieg AM (1996) CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon gamma. Proc Natl Acad Sci USA. 93: 2879.
Krieg AM, Yi A, Matson S, Waldschmidt TJ, Bishop G, et al. (1995) CpG motifs in bacterial DNA trigger direct B-cell activation. Nature. 374: 546.
Klinman DM, Higgins KW, Conover J (1991) Sequential immunizations with rgp120s from independent isolates of human immunodeficiency virus type 1 induce the preferential expansion of broadly crossreactive B cells. J Exp Med. 173: 881.
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