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David H. Margulies

Chief
Molecular Biology Section
Laboratory of Immunology
United States of America

Scientist Immunology
Biography

Dr. Margulies received an A.B. from Columbia University in 1971. In 1978, he earned his M.D. and Ph.D. from the Albert Einstein College of Medicine. From 1978 to 1980, he served as a resident in medicine at Columbia/Presbyterian Medical Center. From 1980 to 1983, he worked as a research associate in the Laboratory of Molecular Genetics at the National Institute of Child Health and Human Development. From 1983 to 1987, he was an investigator in the Laboratory of Immunology. In 1987, he became a senior investigator and, since 1989, has been chief of the Molecular Biology Section. Since 2008, he has been a member of the Senior Biomedical Research Service.

Research Intrest

MHC class I and class II molecules, Viral immunoevasins and related molecules

List of Publications
Revilleza MJ, Wang R, Mans J, Hong M, Natarajan K, Margulies DH. How the virus outsmarts the host: function and structure of cytomegalovirus MHC-I-like molecules in the evasion of natural killer cell surveillance. BioMed Research International. 2011 Jun 30;2011.
Norcross MA, Luo S, Lu L, Boyne MT, Gomarteli M, Rennels AD, Woodcock J, Margulies DH, Mcmurtrey C, Vernon S, Hildebrand WH. Abacavir induces loading of novel self-peptides into HLA-B* 57: 01: an autoimmune model for HLA-associated drug hypersensitivity. AIDS (London, England). 2012 Jul 17;26(11):F21.
Mage MG, Dolan MA, Wang R, Boyd LF, Revilleza MJ, Robinson H, Natarajan K, Myers NB, Hansen TH, Margulies DH. The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. The Journal of Immunology. 2012 Aug 1;189(3):1391-9.
Wang R, Natarajan K, Revilleza MJ, Boyd LF, Zhi L, Zhao H, Robinson H, Margulies DH. Structural basis of mouse cytomegalovirus m152/gp40 interaction with RAE1γ reveals a paradigm for MHC/MHC interaction in immune evasion. Proceedings of the National Academy of Sciences. 2012 Dec 18;109(51):E3578-87.
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