Connie Westhoff

Executive Scientific Director
Complement Biology
Complement Biology, New York Blood Center
United States of America

Scientist Haematology
Biography

"The primary focus of the laboratory is to improve transfusion practice through the use of genomics to bring personalized medicine to the field with a focus on patients with Sickle Cell Disease (SCD). The discovery that patients with SCD have increase RH genetic diversity has led to our current studies to address alloimmunization by implementing genetic matching. A second focus is on the production of cultured RBCs (cRBCs) from stem and iPS cells, which hold the promise of revolutionizing the existing RBC supply system, however the number of cells and the cost of production remain major road blocks. Our goal is to generate clinically useful rare reagent cRBCs to improve and expedite patient workups. This lays the foundation for the future by providing clinically useful products that require relatively small amounts achievable with today’s technology."

Research Intrest

Blood Group Genomics

List of Publications
Westhoff CM, Sipherd BD, Toalson LD (1993) Red cell antigen stability in K3EDTA. Immunohematology 9: 109-111.
Westhoff CM, Sipherd BD, Wylie DE, Toalson LD (1992) Severe anaphylactic reactions following transfusions of platelets to a patient with anti-Ch. Transfusion 32: 576-579.
Chen ZX, Green D, Westhoff C, Spreitzer RJ (1990) Nuclear mutation restores the reduced CO2/O2 specificity of ribulosebisphosphate carboxylase/oxygenase in a temperature-conditional chloroplast mutant of Chlamydomonas reinhardtii. Arch Biochem Biophys 283: 60-67.