Biography

Dr. Dai received his medical and M.S. degrees from Tianjin Medical University, China. As a graduate student, he used mouse models to study gliomagenesis with Dr. Eric Holland at MD Anderson Cancer Center in Houston and Memorial Sloan Kettering Cancer Center in New York. After earning his Ph.D. degree from The University of Texas Health Science Center Houston in 2003, he worked with Dr. Susan Lindquist at the Whitehead Institute for Biomedical Research in Boston to study the role of the proteotoxic stress response in tumorigenesis. In 2009, he joined The Jackson Laboratory in Bar Harbor as an Assistant Professor and was promoted to Associate Professor in May 2016. In October 2016, he joined the Mouse Cancer Genetics Program (MCGP) as an Earl Stadtman Investigator. Dr. Dai received a Children’s Tumor Foundation Young Investigator Award in 2006, an Ellison Medical Foundation New Scholar in Aging Award in 2009, and a NIH Director’s New Innovator Award in 2010. 

Research Intrest

Cancer Biology, Cell Biology, Genetics and Genomics, Molecular Biology and Biochemistry 

List of Publications
Dai C, Celestino JC, Okada Y, Louis DN, Fuller GN, et al. (2001) PDGF autocrine stimulation dedifferentiation cultured astrocytes and induces oligodendrogliomas and oligoastrocytomas from neural progenitors and astrocytes in vivo. Genes and Development 15: 1913-1925.
Dai C, Whitesell L, Rogers A, Lindquist S (2007) Heat shock factor 1 (HSF1) is a powerful multifaceted modifier of carcinogenesis. Cell. 130: 1005-1018.
Dai S, Tang Z, Cao J, Zhou W, Li H, et al. (2015) Suppression of the HSF1-mediated proteotoxic stress response by the metabolic stress sensor AMPK. EMBO Journal. 34: 275-293
Tang Z, Dai S, He Y, Doty RA, Shultz LD, et al. (2015) MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1. Cell. 160: 729-744
Su KH, Cao J, Dai S, Tang Z, He Y,et al. (2016) HSF1 critically attunes proteotoxic-stress sensing by mTORC1 to combat stress and promote growth. Nature Cell Biology. 18: 527-539