Bruno Permanne is the Head of Biology at Asceneuron. He is responsible for planning and supervision of assay development and pharmacology activities.  Bruno is a neurobiologist with over 15 years of experience in drug discovery programs on neurodegenerative diseases (Alzheimer’s disease, Parkinson’s disease and tauopathies). At Asceneuron he focuses on the O-GlcNAcase inhibitor program and biomarker development. Previously he was a project team leader at Merck Serono, Switzerland, where he successfully ran early discovery programs resulting in the progression of small molecules from high-throughput screens to lead optimization stage.  Bruno obtained his PhD in biochemistry at the University of Lille under the co-supervision of Drs Andre Delacourte and Luc Buée.  Subsequently he joined the laboratory of Professor Blas Frangione at the NYU Medical Center, USA, as a postdoc. Both groups are internationally recognized for their work on the pathophysiology of the tau protein and amyloidogenesis in neurodegenerative diseases.  He is the author of 13 peer-reviewed publications.

neurodegenerative diseases  progression of small molecules from high-throughput screens to lead optimization stage