Bruce Sachais

Executive Medical Director
Complement Biology
Complement Biology, New York Blood Center
United States of America

Scientist Haematology
Biography

The Platelet Research Laboratory is interested in the pathobiology of platelets and platelet molecules. We are currently focused on improved diagnosis and novel therapeutics for heparin induced thrombocytopenia/thrombosis (HITT). We have recently published on novel assays which may improve the precision and accuracy for diagnosis HITT. Have also published on novel small molecules that interfere with the formation of heparin:PF4 complexes, which we call PF4 Antagonists (POF4As). We are actively working to improve the potency and pharmacology of PF4As towards the development of PF4As as a therapeutic option for the treatment and/or prevention of HIT. We are also interested in the pathgobiology of HIT as well as other platelet disorders.

Research Intrest

Platelet Research

List of Publications
Parker ZF, Rux AH, Riblett AM, Lee FH, Rauova L, et al. (2016) Platelet Factor 4 Inhibits and Enhances HIV-1 Infection in a Concentration-Dependent Manner by Modulating Viral Attachment. AIDS Res Hum Retroviruses 32: 705-717.
Sarode R, Ballas SK, Garcia A, Kim HC, King K, et al. (2016) Red blood cell exchange: 2015 American Society for Apheresis consensus conference on the management of patients with sickle cell disease. J Clin Apher
Sachais BS (2016) American Society for Apheresis (ASFA) sets new exam. Transfus Apher Sci 55: 171.