Beatriz Mothe

Associate researcher
Host Genetics and Cellular Immunity
Spain

Biography

Born in Lleida in 1977, Beatriz Mothe, MD, PhD, has been employed at IrsiCaixa since 2007. Her PhD, completed under a national competitive post-specialization programme for physicians (ISCIII Rio Hortega CM08/00020 2009-2011) was on the subject of immunological, virological and genetic HIV-control mechanisms that could be incorporated into the rational design of novel therapeutic vaccine candidates (Catalan Award for Best Thesis on Infectious Diseases in 2012). She has actively participated in pre-clinical testing of a novel HIV T-cell immunogen called HTI, designed to redirect cytotoxic T-cell responses to protective and conserved HIV targets capable of controlling viral replication. Following US research stays at the Ragon Institute of MGH, MIT and Harvard (formerly Partners AIDS Research Center) and the National Cancer Institute at Frederick, she took up a research fellowship position (ISCIII Joan Rodés JR13/00024 2014-2016) associated with the Host Genetics and Cellular Immunology group led by Dr. Brander in IrsiCaixa. She also works part-time in the HIV unit of the Germans Trias i Pujol University Hospital, where she identifies and monitors acute/recent HIV infection and HIV controllers as models for a functional cure (principal investigator for the early-cART and controller cohorts). As a clinical researcher with a strong translational profile, she coordinates clinical trials and immune monitoring in aspects related to therapeutic vaccines and eradication strategies. She has taught on the MSc in AIDS Pathogenesis and Treatment since 2012 and, with Dr. Brander, is currently co-directing a doctoral thesis on the subject of advanced immunology for the Autonomous University of Barcelona (UAB). She has been an associate professor in the Faculty of AIDS and Related Diseases at the University of Vic-University of Central Catalonia (UVic-UCC) since 2014.

Research Intrest

HIV therapeutics, HIV vaccines, Immunotherapy, Functional cure  

List of Publications
Ruiz-Riol, M., Llano, A., Ibarrondo, J., Zamarreño, J., Yusim, K., Bach, V., … Brander, C. (2015). Alternative Effector-Function Profiling Identifies Broad HIV-Specific T-Cell Responses in Highly HIV-Exposed Individuals Who Remain Uninfected. The Journal of Infectious Diseases, 211(6), 936–946.
Beatriz Mothe Nuria Climent Montserrat Plana Miriam Rosàs José Luis Jiménez María Ángeles Muñoz-Fernández María C. Puertas Jorge Carrillo Nuria Gonzalez Agathe León ... Show more Journal of Antimicrobial Chemotherapy, Volume 70, Issue 6, 1 June 2015, Pages 1833–1842,
Mothe, B., Hu, X., Llano, A., Rosati, M., Olvera, A., Kulkarni, V., … Brander, C. (2015). A human immune data-informed vaccine concept elicits strong and broad T-cell specificities associated with HIV-1 control in mice and macaques. Journal of Translational Medicine, 13, 60.
Mothe, B., Llano, A., Ibarrondo, J., Daniels, M., Miranda, C., Zamarreño, J., … Brander, C. (2011). Definition of the viral targets of protective HIV-1-specific T cell responses. Journal of Translational Medicine, 9, 208.
Mothe, B., Llano, A., Ibarrondo, J., Zamarreño, J., Schiaulini, M., Miranda, C., … Brander, C. (2012). CTL Responses of High Functional Avidity and Broad Variant Cross-Reactivity Are Associated with HIV Control. PLoS ONE, 7(1), e29717.