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B. J. Fowlkes

Chief
T Cell Development Section
Laboratory of Immunology
United States of America

Scientist Immunology
Biography

After receiving an M.S. from the Medical College of Virginia, VCU, for studies of Drosophila genetics, Dr. Fowlkes conducted cancer research at the National Cancer Institute (NCI) and immunology research at NIAID prior to receiving her Ph.D. for studies of thymocyte differentiation at George Washington University. She joined the Laboratory of Cellular and Molecular Immunology (LCMI) in 1987, was tenured as a senior investigator in 1990, and became chief of the T-Cell Development Section (TCDS) in 1992. In 2013, she joined the Laboratory of Immunology (LI).

Research Intrest

GATA3 in T cell activation, differentiation, and lineage commitment

List of Publications
Laky K, Fowlkes BJ. Presenilins regulate αβ T cell development by modulating TCR signaling. Journal of Experimental Medicine. 2007 Sep 3;204(9):2115-29.
Laky K, Fowlkes BJ. Notch signaling in CD4 and CD8 T cell development. Current opinion in immunology. 2008 Apr 30;20(2):197-202.
Wang L, Wildt KF, Zhu J, Zhang X, Feigenbaum L, Tessarollo L, Paul WE, Fowlkes BJ, Bosselut R. Distinct functions for the transcription factors GATA-3 and ThPOK during intrathymic differentiation of CD4+ T cells. Nature immunology. 2008 Oct 1;9(10):1122-30.
Notch signaling regulates antigen sensitivity of naive CD4(+) T cells by tuning co-stimulation.
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