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Andre Nussenzweig

Laboratory of Genome Integrity
The Center for Cancer Research
United States of America

Scientist Immunology
Biography

Dr. Nussenzweig received his Ph.D. in Physics from Yale University in 1989. He completed his postdoctoral training in atomic physics in Paris with Dr. Serge Haroche, who was awarded the Nobel prize in Physics in 2012. Subsequently, Dr. Nussenzweig became a Research Fellow at Memorial Sloan-Kettering Cancer Center prior to joining the Experimental Immunology Branch as a tenure track investigator in 1998. Dr. Nussenzweig received tenure at NIH in 2003. In 2011, Dr. Nussenzweig established a new department at NCI called the Laboratory of Genome Integrity. Dr. Nussenzweig is an elected member of the European Molecular Biology Organization and a National Institutes of Health Distinguished Investigator. 

Research Intrest

Cancer Biology, Chromosome Biology, Immunology, Stem Cell Biology 

List of Publications
Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, et al. (2013) Identification of early replicating fragile sites that contribute to genome instability. Cell. 152: 620-32.
Callen E, Di Virgilio M, Kruhlak MJ, Nieto-Soler M, Wong N, et al. (2013) 53BP1 mediates productive and mutagenic DNA repair through distinct phosphoprotein interactions. Cell. 153: 1266-80.
Santos MA, Faryabi RB, Ergen AV, Day AM, Malhowski A, et al. (2014) DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier. Nature. 514: 107-11.
Ray Chaudhuri A, Callen E, Ding X, Gogola E, Duarte AA, et al. (2016) Replication fork stability confers chemoresistance in BRCA-deficient cells. Nature. 535: 382-7.
Canela A, Maman Y, Jung S, Wong N, Callen E, et al. (2017) A Genome Organization Drives Chromosome Fragility. Cell. 170: 507–521.
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