Zeynep Madak-Erdogan

Assistant Professor
Division of Nutritional Sciences
University of Illinois at urbana champaign
United States of America

Professor Nutrition
Biography

She has done her B.S. Bilkent University Ankara, Turkey 1998-2002, Ph.D. University of Illinois,Urbana-Champaign Urbana, IL, USA 2004-2009. She improves the quality of life for postmenopausal women and breast cancer survivors by understanding how diet and nutrition affect hormone action. Her lab uses multiscale modeling of –omics data from patient samples, animal models, and cell lines to understand the molecular basis of metabolic regulation by estrogen receptors and endocrine resistance.

Research Intrest

Integrating -OMICs data from RNA-Seq, ChIP-Seq and Metabolomics experiments to understand the molecular basis of metabolic syndrome and cancer Keywords: Nutrigenomics, Biomarker development, Transcriptomics, Cistromics, Metabolomics, Obesity, Breast cancer, Personalized medicine. Role of novel synthetic and natural estrogens on metabolic health of post-menopausal women Keywords: Obesity, Metabolic Syndrome, Genomic and Non-genomic ER signaling, Genomics, Metabolomics. Impact of Estrogen Receptor alpha and kinase signaling cross-talk on development and progression of breast cancer Keywords: Breast cancer, ER signaling, Kinase, Genomics, Endocrine Resistance.

List of Publications
Madak-Erdogan Z., Ventrella R, Petry L., Katzenellenbogen BS, Novel Roles for ERK5 and Cofilin as Critical Mediators Linking ERalpha-Driven Transcription, Actin Reorganization and Invasiveness in Breast Cancer., Molecular Cancer Research, 2014 May;12(5):714-27, PMID: 24505128
Kim SH, Madak-Erdogan Z, Bae SC, Carlson KE, Mayne CG, Granick S, Katzenellenbogen BS, Katzenellenbogen JA. Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History, J Am Chem Soc. 2015 Aug 19;137(32):10326-35.
Madak-Erdogan Z, Gong P, Katzenellenbogen BS., Differential utilization of nuclear and extranuclear receptor signaling pathways in the actions of estrogens, SERMs, and a tissue-selective estrogen complex (TSEC). J Steroid Biochem Mol Biol. 2015 Dec 12