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Wolfram Goessling

Associate Professor
Departmaent of Medicine
Harvard Medical School
United States of America

Professor Haematology
Biography

Dr. Goessling is a Professor of Medicine and of Health Sciences and Technology at Harvard Medical School. He received his MD and doctorate from the University of Witten/Herdecke in Germany. He trained in Internal Medicine at Brigham and Women's Hospital, served as Chief Medical Resident, and completed fellowship training in Hematology/Oncology at the combined Dana-Farber/Partners program and in Gastroenterology at Massachusetts General Hospital. Dr. Goessling pursued his postdoctoral research with Dr. Leonard Zon at Children’s Hospital, using zebrafish to characterize regulators of liver development, regeneration and cancer. He sees patients with liver disease and liver cancer at Dana-Farber Cancer Institute and Brigham and Women’s Hospital.

Research Intrest

Cancer LiverDisease Metabolic Regulation of Liver Growth A Community Zebrafish Resource for Modeling GWAS Biology Mutant mapping and identification in zebrafish by next generation sequencing  

List of Publications
Liu LY, Alexa K, Cortes M, Schatzman-Bone S, Kim AJ, Mukhopadhyay B, Cinar R, Kunos G, North TE, Goessling W. Cannabinoid receptor signaling regulates liver development and metabolism. Development. 2016 Feb 15; 143(4):609-22. PMID: 26884397; PMCID: PMC4760316 [Available on 02/15/17].
Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, Zhang F, Goessling W, Zapol WM, Mootha VK. Hypoxia as a therapy for mitochondrial disease. Science. 2016 Apr 01; 352(6281):54-61. PMID: 26917594; PMCID: PMC4860742 [Available on 10/01/16].
Raman M, Sergeev M, Garnaas M, Lydeard JR, Huttlin EL, Goessling W, Shah JV, Harper JW. Corrigendum: Systematic proteomics of the VCP-UBXD adaptor network identifies a role for UBXN10 in regulating ciliogenesis. Nat Cell Biol. 2016 Mar; 18(3):347. PMID: 26911913.
Goessling W, North TE. EnaBILEing Growth in the Fetal Liver. Cell Stem Cell. 2016 Apr 07; 18(4):427-8. PMID: 27058931.
Goessling W, Stainier DY. Endoderm specification and liver development. Methods Cell Biol. 2016; 134:463-83. PMID: 27312502.
Bao XR, Ong SE, Goldberger O, Peng J, Sharma R, Thompson DA, Vafai SB, Cox AG, Marutani E, Ichinose F, Goessling W, Regev A, Carr SA, Clish CB, Mootha VK. Mitochondrial dysfunction remodels one-carbon metabolism in human cells. Elife. 2016 Jun 16; 5. PMID: 27307216; PMCID: PMC4911214.
Kwan W, Cortes M, Frost I, Esain V, Theodore LN, Liu SY, Budrow N, Goessling W, North TE. The Central Nervous System Regulates Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling. Cell Stem Cell. 2016 Sep 01; 19(3):370-82. PMID: 27424782.
Walesky C, Goessling W. Nature and nurture: Environmental toxins and biliary atresia. Hepatology. 2016 Sep; 64(3):717-9. PMID: 27349921.
Cox AG, Tsomides A, Kim AJ, Saunders D, Hwang KL, Evason KJ, Heidel J, Brown KK, Yuan M, Lien EC, Lee BC, Nissim S, Dickinson B, Chhangawala S, Chang CJ, Asara JM, Houvras Y, Gladyshev VN, Goessling W. Selenoprotein H is an essential regulator of redox homeostasis that cooperates with p53 in development and tumorigenesis. Proc Natl Acad Sci U S A. 2016 Sep 20; 113(38):E5562-71. PMID: 27588899.
Cortes M, Chen MJ, Stachura DL, Liu SY, Kwan W, Wright F, Vo LT, Theodore LN, Esain V, Frost IM, Schlaeger TM, Goessling W, Daley GQ, North TE. Developmental Vitamin D Availability Impacts Hematopoietic Stem Cell Production. Cell Rep. 2016 Oct 04; 17(2):458-468. PMID: 27705794.
North TE, Goessling W. Haematopoietic stem cells show their true colours. Nat Cell Biol. 2016 Dec 23; 19(1):10-12. PMID: 28008181.
Walesky C, Goessling W. WNTing no RASt for hepatocellular carcinoma. Hepatology. 2017 May; 65(5):1435-1437. PMID: 28295459.
Kroeger PT, Drummond BE, Miceli R, McKernan M, Gerlach GF, Marra AN, Fox A, McCampbell KK, Leshchiner I, Rodriguez-Mari A, BreMiller R, Thummel R, Davidson AJ, Postlethwait J, Goessling W, Wingert RA. The zebrafish kidney mutant zeppelin reveals that brca2/fancd1 is essential for pronephros development. Dev Biol. 2017 Aug 01; 428(1):148-163. PMID: 28579318.
Experts in United States of America
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