Dr. William  T.  Doerrler  is currently working as a Associate Professor  in the Department of Department of Biological Sciences, Louisiana State University , USA. His research interests includes Bacterial resistance to biocides, antibiotics is an increasing problem, numerous unrelated drugs, Protein Tvp38, E. coli cell division. He is serving as an editorial member and reviewer of several international reputed journals. Dr. William  T.  Doerrler  is the member of many international affiliations. He has successfully completed his Administrative responsibilities. He has authored of many research articles/books related to Bacterial resistance to biocides, antibiotics is an increasing problem, numerous unrelated drugs, Protein Tvp38, E. coli cell division.

Bacterial resistance to biocides and antibiotics is an increasing problem. Resistance is often conferred by expression of membrane-embedded efflux pumps that can accommodate numerous unrelated drugs. We have discovered a new family of membrane transporters required for multidrug resistance in Escherichia coli. This family is called the DedA/Tvp38 family in public databases based upon similarity to E. coli DedA and Yeast Golgi apparatus membrane protein/SNARE Associated Protein Tvp38. Currently, there are thousands of DedA family genes in the online protein database and they are present in most genomes. They display no significant amino acid identity to protein families of known function including all known membrane transporter families. We have shown that members of the DedA family are required for E. coli cell division, growth at elevated temperatures, and maintenance of the membrane protonmotive force and drug resistance. Future studies are aimed at characterizing these and other members of the conserved and widespread DedA family.