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William Grady

Professor
Gastroenterology
Fred Hutchinson Cancer Rearch Center
United States of America

Professor Gastroenterology
Biography

Dr. Grady specializes in gastroenterology and internal medicine. His particular clinical interests include the diagnosis and treatment of hereditary cancer syndromes, as well as the development and use of molecular markers for the prevention and treatment of colon, esophageal and stomach cancer. He received his medical degree from the University of Michigan Medical School and was the internal medicine chief resident at the University of Washington School of Medicine. He did his gastroenterology fellowship at Case Western Reserve University and then was on faculty at Vanderbilt University before moving to Seattle. He is currently the UW Rodger C. Haggitt professor of medicine and director of translational research of the gastroenterology section at UWMC. He is also a full member of the Fred Hutchinson Cancer Research Center, Clinical Research Division and the medical director of the GI Cancer Prevention Program Clinic at the Seattle Cancer Care Alliance.

Research Intrest

Molecular markers; colorectal polyps; colorectal cancer; Barrett's esophagus; esophageal cancer; cancer epigenetics; cell signaling.

List of Publications
Williams CD, Grady WM, Zullig LL. 2016. Use of NCCN Guidelines, Other Guidelines, and Biomarkers for Colorectal Cancer Screening.. Journal of the National Comprehensive Cancer Network : JNCCN. 14(11):1479-1485
Fischer JM, Calabrese PP, Miller AJ, Muñoz NM, Grady WM, Shibata D, Liskay MR. 2016. Single cell lineage tracing reveals a role for TgfβR2 in intestinal stem cell dynamics and differentiation.. Proceedings of the National Academy of Sciences of the United States of America. 113(43):12192-12197.
Bosch LJW, Luo Y, Lao VV, Snaebjornsson P, Trooskens G, Vlassenbroeck I, Mongera S, Tang W, Welcsh P, Herman JG et al.. 2016. WRN promoter CpG island hypermethylation does not predict more favorable outcomes for metastatic colorectal cancer patients treated with irinotecan-based therapy.. Clinical cancer research : an official journal of the American Association for Cancer Research. 22(18):4612-4622
Cui J, Cai Y, Hu Y, Huang Z, Luo Y, Kaz AM, Yang Z, Chen D, Fan X, Grady WM et al.. 2016. Epigenetic silencing of TPM2 contributes to colorectal cancer progression upon RhoA activation.. Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 37(9):12477-12483.
Parang B, Kaz AM, Barrett CW, Short SP, Ning W, Keating CE, Mittal MK, Naik RD, Washington MK, Revetta FL et al.. 2017. BVES regulates c-Myc stability via PP2A and suppresses colitis-induced tumourigenesis.. Gut. 66(5):852-862.
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