He is currently working as a in National chiayi university in the Department of Applied Chemistry. He has completed his Ph.D. from Georgia Institute of Technology (1992). His Research Area includes Analytical Chemistry, Biophysical Chemistry. He is interested in the development of Raman Techniques (Dispersive Raman, FT-Raman, and Surface Enhanced Raman Scattering) to explore bioactive molecules of natural products and to characterize molecular structure of biomacromolecules. Raman spectroscopy is well known for its capability of providing rich molecular information. However, the application of Raman technique in studying natural pigments is usually hampered by the strong fluorescence signals arising from the intrinsic chromophores/fluorphors of natural pigments in plant. To overcome this problem, the development of Fourier transform Raman spectroscopy (FT-Raman) excited at near-infrared wavelength has demonstrated tremendous breakthrough. Although FT-Raman has made much progress in relaxing fluorescence interference and also has exhibited much spectroscopic superiority such as simple, direct, and free from photo bleaching due to the advantages of near infrared excitation, and the high throughput and multiplex characteristics of Michelson interferometer, it remains suffering from the shortcoming of low sensitivity, particularly for the solutions at low concentration. Therefore, to develop a high sensitive Raman technique to characterize nature pigments remains an important issue. With the aid of nano technique, we are developing surface-enhanced Raman scattering (SERS) to be an excellent ultra sensitive tool in probing trace molecules of natural pigments such as catechins and anthocyanins, of which Raman signals are usually overwhelmed by the strong fluorescence arising from their intrinsic chromophores/fluorphors. Research projects for this part include: (1) Separation, purification, and identification of bioactive compounds from Yam (2) Raman spectroscopic study of natural pigments such as catechin and anthocyanin (3) Developing ultrasensitive Raman detection system.

Analytical Chemistry, Biophysical Chemistry