Dr. Shen joined Georgetown University Division of Nephrology after she completed her training at Harvard. She is actively involved in patient care, teaching medical trainees and research. Her clinical work focuses on patients with hypertension, chronic kidney disease, primary and secondary glomerulonephritis, polycystic kidney disease, congenital kidney disease, kidney stones, and electrolyte disorders.

Her interest in understanding the mechanisms of proteinuria and developing new therapies for patients with proteinuric CKD has led her to involvement in several clinical and translational research projects. Currently, she is leading a clinical trial that investigates a new approach to treat proteinuric kidney disease by inhibiting the urokinase-type plasminogen activator receptor and renal tubular epithelial sodium channel. She is also the principle investigator of a clinical study examing if proteinuria independently predicts post-operative acute kidney injury by using big database. In addition, she is involved in a translational research project to study the cross talk between brain and kidney. She serves as a member of the Internal Review Board at Georgetown. She also oversees medical student's scholarly activities by serrving as a member of Independent Scholarly Project Oversight Committee.