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Warren Heston

Staff
Cancer Biology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Medicine
Biography

Our laboratory has cloned and characterized the expression of the mRNA encoding prostate-specific membrane antigen (PSMA); sequenced human and mouse PSMA DNA; generated PSMA knockout mice;identified the PSMA enhancer.

Research Intrest

Prostate cancer; prostate-specific membrane antigen; therapeutics; imaging

List of Publications
"NAAG peptidase inhibitors and deletion of NAAG peptidase gene enhance memory in novel object recognition test. Janczura KJ, Olszewski RT, Bzdega T, Bacich DJ, Heston WD, Neale JH: Eur J Pharmacol Nov 29 2012 epub ahead of print.
Sunitinib malate provides activity against murine bladder tumor growth and invasion in a preclinical orthotopic model. Chan ES, Patel ER, Hansel DE, Larchian WA, Heston WD: Urology 80: 736 1-5, 2012.
In vitro and in vivo responses of advanced prostate tumors to PSMA ADC an auristatin-conjugated antibody to prostate-specific membrane antigen. Wang X, Ma D, Olson WC, (2011) Heston WD. Mol Cancer Ther. 10: 1728-1739.
Experts in United States of America
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