1987 B.Medicine, Fudan University Medical School, China, 1996 Ph.D in Biological Chemistry, UCLA, USA, 1996-2003 Postdoc,Stanford University, USA, 2003-2015 Assistant Professor, Associate Professor, Research Scientist, Yale University, USA. 2015-present Professor, ShanghaiTech University, China, 2016-present Adjunct Professor, Dept Immunobiology, Yale University, USA.

（1）Transgenerational epigenetic inheritance. Environmental stimuli such as diet, toxins, stress and emotions can induce persistent changes in gene activity without mutating DNA, and surprisingly, such changes can sometimes be propagated to the offspring. Thus, our traits are determined not only by our genes, but also the life experiences and even the emotions of our ancestors (http://tv.greenmedinfo.com/the-ghost-in-your-genes-epigenetics/). This amazing phenomenon is turning classic genetics on its head, but its molecular basis is complex. We have established the simplest mouse model to attack this problem10,11. （2）Mouse genetic tools. Convinced that technology is the mother of scientific discoveries, we have developed multiple mouse genetic tools3,7,8,9, with the current focus being high-throughput screening. For the majority of genes, we only know their sequences but not the functions. High-throughput screening is a powerful approach for unveiling gene functions, but it can only be performed in vitro, which severely restricts its applications and constitutes a major bottleneck in genetics, as most of the biological processes can not be (readily) recapitulated in vitro. We are taking a novel molecular genetic strategy (that combines Cre with Cas9) to break this bottleneck, and will eventually use our method to uncover the functions of genes(especially LncRNA genes)in live mice.