SWATI NAGAR

Associate Professor
Department of Pharmaceutical Sciences
Temple University
United States of America

Biography

Swati Nagar obtained her Ph.D. in Pharmaceutics at the University of Minnesota in 2003. She completed a postdoctoral fellowship in Pharmacology at Fox Chase Cancer Center in 2005. Swati joined Temple University School of Pharmacy, Department of Pharmaceutical Sciences in 2005 as Assistant Professor, and was promoted to the rank of Associate Professor in 2011. She teaches Pharm D and graduate pharmacokinetics. Swati’s research focuses on enzyme kinetics and in collaboration with Dr. Ken Korzekwa she is developing methods to better understand complex kinetics of time-dependent inhibition. Another key collaborative area of research with the Korzekwa lab is developing models to predict intracellular concentrations in the presence of drug transporters. Additionally, her lab has a long-standing interest in understanding the disposition of conjugated metabolites, specifically the pharmacokinetics of metabolites with respect to their formation and transport. Swati is the current Chair of the Delaware Valley Drug Metabolism Discussion Group, current Chair of the AAPS PPDM Drug Metabolism Focus Group, a member of the steering committee of the International Transporter Consortium, and a member of several professional organizations such as AAAS, ASPET, AAPS and ISSX. She is currently serving on the editorial board of Drug Metabolism and Disposition.

Research Intrest

Swati’s research interests are enzyme kinetics and in collaboration with Dr. Ken Korzekwa she is developing methods to better understand complex kinetics of time-dependent inhibition. Another key collaborative area of research with the Korzekwa lab is developing models to predict intracellular concentrations in the presence of drug transporters. Additionally, her lab has a long-standing interest in understanding the disposition of conjugated metabolites, specifically the pharmacokinetics of metabolites with respect to their formation and transport.

List of Publications
Argikar UA, Nagar S. (2014) Editors: Nagar S, Argikar UA, Tweedie DJ, Practical analytical considerations in enzyme kinetic studies in ‘Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications’. Series: Methods in Molecular Biology Vol. 1113, ISBN 978-1-62703-757-0. Springer / Humana Press.
Nagar S. Editors: Raffa RB, Tallarida RJ (2010) Pharmacokinetics of anti-cancer drugs used in breast cancer chemotherapy in ‘Chemofog: Cancer Chemotherapy-Induced Cognitive Deficits’ pp 124 – 132; Landes Bioscience Inc. Austin TX.
Nagar S, Argikar UA, Tweedie DJ (2014) Editors: Nagar S, Argikar UA, Tweedie DJ, Application of enzyme kinetics in drug metabolism studies in ‘Enzyme Kinetics in Drug Metabolism: Fundamentals and Applications’. Series: Methods in Molecular Biology Vol. 1113, ISBN 978-1-62703-757-0. Springer / Humana Press.
Nagar S, Remmel RP, Hebbel RP, and Zimmerman CL (2004) Metabolism of opioids is altered in liver microsomes of sickle cell transgenic mice. Drug Metabolism and Disposition 32:98-104.
Nagar S, Zalatoris JJ, and Blanchard RL (2004) Human UGT1A6 Pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics 14:487 – 499.

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