Sonika Patial

Associate Professor
Comparative Biomedical Sciences
Louisiana State University
United States of America

Biography

DVM - College of Veterinary and Animal Sciences, Palampur, India, 2003 MS - Indian Veterinary Research Institute, Izatnagar, India, 2005 PhD - Michigan State University, East Lansing, MI, 2010 Postdoctoral fellowship - National Institute of Environmental Health Sciences, Research Triangle Park, NC, 2015 Residency in Anatomic Pathology - Louisiana State University, Baton Rouge, LA, 2016

Research Intrest

Innate immunity is a highly conserved response that quickly detects and attempts to clear pathogens and harmful environmental stimuli by inducing inflammatory responses. These responses are orchestrated via temporal and highly coordinated regulation of a number of genes. In addition to regulation at the transcriptional level, a majority of these genes are also regulated by post-transcriptional mechanisms that modify mRNA stability and/or translation. The focus of our research is to understand the association between environmental stimuli, post-transcriptional mechanisms of gene expression, and disease pathogenesis. We are specifically interested in: 1) understanding how environmental exposures affect post-transcriptional mechanisms, in order to cause inflammation and immune-mediated disease; 2) understanding how post-transcriptional mechanisms induce changes in gene expression that confer competitive advantage to cancerous cells and contribute to tumor development.

List of Publications
Sonika Patial, Deborah J. Stumpo, W. Scott Young III, James M. Ward, Gordon Flake, and Perry J. Blackshear. Effects of combined tristetraprolin/tumor necrosis factor receptor deficiency on the splenic transcriptome. Molecular and Cellular Biology 36(9): 1395-411.
Early Postnatal Secondhand Smoke Exposure Disrupts Bacterial Clearance and Abolishes Immune Responses in Muco-Obstructive Lung Disease., Lewis, B; Sultana, R; Sharma, R; Noel, Alexandra; Langohr, Ingeborg; Patial, Sonika; Penn, Arthur; Saini, Yogesh, 2017, Journal of immunology (Baltimore, Md. : 1950)
Sonika Patial and Perry J. Blackshear. Tristetraprolin as a therapeutic target in inflammatory disease. Trends in Pharmacological sciences 37(10): 811-21.