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Shiuan Chen

Chair and Professor
CANCER BIOLOGY
Beckman Research Institute
United States of America

Professor Oncology
Biography

Dr. Chen has studied the role of aromatase in breast cancer development for more than 20 years. Currently Dr. Chen's research explores the mechanisms of endocrine resistance in breast cancer cells and seeks to understand the structure-function relationship of the aromatase protein in order to develop chemoprevention strategies using phytochemicals with anti-aromatase activity. His laboratory also investigates the impact of environmental chemicals on human health by modulating aromatase activity and expression.

Research Intrest

Chemoprevention Research Program Breast Cancer Translational Research Program in Natural Therapies

List of Publications
Cao H, Mu Y, Li X, Wang Y, Chen S, Liu JP. A systematic review of randomized controlled trials on oral chinese herbal medicine for prostate cancer. PloS one. 2016 Aug 4;11(8):e0160253.
Kanaya N, Somlo G, Wu J, Frankel P, Kai M, Liu X, Wu SV, Nguyen D, Chan N, Hsieh MY, Kirschenbaum M. Characterization of patient-derived tumor xenografts (PDXs) as models for estrogen receptor positive (ER+ HER2− and ER+ HER2+) breast cancers. The Journal of steroid biochemistry and molecular biology. 2017 Jun 30;170:65-74.
Wang Y, Zhou D, Phung S, Warden C, Rashid R, Chan N, Chen S. SGK3 sustains ERα signaling and drives acquired aromatase inhibitor resistance through maintaining endoplasmic reticulum homeostasis. Proceedings of the National Academy of Sciences. 2017 Feb 21;114(8):E1500-8.
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