Shisheng Li

Professor
Comparative Biomedical Sciences
Louisiana State University
United States of America

Biography

Dr. Shisheng Li is currently working as Professor in School of Veterinary Medicine. Bachelor's Degree(s): Henan Normal University, China; Master's Degree: Nankai University, China; PhD: University of Wales Swansea, UKH is research interests are Comparative Biomedical Sciences, biotransformation etc

Research Intrest

Both normal metabolic activities and environmental factors such as solar UV light, radiation and industrial pollutants can cause damage to cellular DNA, resulting in as many as 1 million lesions per human cell per day. To contend with the constantly occurring DNA lesions, cells are equipped with multiple, highly conserved DNA repair pathways. Deficiencies in DNA repair are implicated in cancer, mental and developmental retardation, and premature aging. Our research is focused on elucidating the molecular mechanisms of DNA repair in living human and yeast cells. Our finding may offer valuable guidance for prevention and/or treatment of human diseases related to DNA damage and repair.

List of Publications
Li, W., Selvam, K., Ko, T. and Li, S. (2014). Transcription bypass of DNA lesions enhances cell survival but attenuates transcription coupled DNA repair. Nucleic Acids Res. 42, 13242-13253.
Li, M., Ko, T. and Li, S (2015). High-resolution digital mapping of N-methylpurines in human cells reveals modulation of their induction and repair by nearest-neighbor nucleotides. J. Biol. Chem. 290, 23148-23161.
Li, S. (2015). Transcription coupled nucleotide excision repair in the yeast Saccharomyces cerevisiae: The ambiguous role of Rad26. DNA Repair. Epub ahead of print