06/2008 – now Senior Research Scientist Orthopaedic Research Institute, Via Christi Health System, Wichita, KS 10/2007 – now Guest Professor Shandong University Affiliated Jinan Central Hospital, Jinan, China 09/2002 – 06/2008 Assistant Professor Department of Orthopaedic Surgery, School of Medicine, Wayne State University 01/2003 – 06/2008 Assistant Professor Department of Biomedical Engineering, College of Engineering, Wayne State University 03/1990 – 02/1994 Research Associate University of Manitoba, Winnipeg, Canada 08/1988 – 03/1990 Staff Surgeon in Orthopaedics Jinan Municipal Central Hospital, Shandong Province, China

Research Projects in Progress: SCID mice model to study the interactions among peripheral blood monocytes, human periprosthetic tissue and bone tissue that lead to wear debris-associated loosening following total joint replacement. Combination gene therapy of anti-inflammation and counter-osteolysis for rheumatoid arthritis using a mouse collagen-induced arthritis model.  A long-term murine model of prosthetic knee joint for implant stability, debris-associated bone resorption and potential gene therapy. Soluble VEGF receptor gene therapy in controlling growth and metastasis of osteosarcoma in a novel mouse model. Engineered bone graft substitutes for large bone defect. The study uses in intro and in vivo approaches to explore the type, composition, porosity, and biocompatibility of biomaterial scaffolds with the bedding and growth of osteo- and endothelial progenitor cells directional inducted from bone marrow stromal cells. Minocyclin-associated bone discoloration and its molecular mechanism.