Dr. Shalini Mani is Senior Assistant Professor in the Department of Biotechnology at Jaypee Institute of Information Technology since Aug 2010. She has been in teaching from 2009 working at Amity University, Noida before joining JIIT. She has also worked as Scientist C in Vimta Life Sciences, Hyderabad during year 2008. She has done her PhD from Centre for Cellular and Molecular Biology, Hyderabad, where she worked on detailed analysis of clinical biochemical and genetic analysis of Leigh syndrome patients and found an interesting geneotype-phenotype correlation of mitochondrial and nuclear gene mutations in these patients. She did her post graduation from G B pant University, Pantnagar in Molecular Biology and Genetic Engineering. Her research work during post graduation and PhD has fetched in to several publications in national and international journals. During her PhD she was a member of one of the participating groups of Indian genome variation consortium IGVdb) since 2003. IGVdb consortium a first step towards identifying susceptible biomarkers for any disease or understanding drug response in different subpopulations. This consortium, therefore, aims at providing information on variations in the subpopulations representing the entire country. These variations would be useful for investigators for specific candidate gene studies conducted in any part of the country. Her current research interest is to explore the mechanism of pathogenic role of mitochondria in common metabolic diseases like cancer and diabetes. Mitochondria, being a powerhouse of the cellular system are a most important organelle. Hence, any perturbation in mitochondrial metabolism may affect several organs and hence cause several diseases/disorders. In the last few decades only, research based on various aspects of mitochondria started coming in to the picture. As result of which mitochondrial defects are suggested to be associated with a large number of metabolic and neurological disorders. However, the research exploring the detailed mechanism of participation of mitochondria, it’s possible defects in causation and or progress of the large number of diseases are still in infancy.

Mechanism of pathogenic role of mitochondria in common metabolic diseases like cancer and diabetes