Scott Abrams

Professor
Department of Immunology
Roswell Park Cancer Institute
United States of America

Professor Oncology
Biography

Dr. Scott Abrams joined the Faculty of Roswell Park Cancer Institute (RPCI) in 2008 and, in 2013, was promoted to Professor of Oncology and Member in the Department of Immunology. He holds a joint appointment as Research Professor on the Graduate Faculty at the State University of New York at Buffalo. Moreover, in 2013, he was appointed as Director of Graduate Studies in the Department of Immunology at RPCI and, in 2014, was reappointed to the UB Graduate Faculty with Distinction.Dr. Abrams came to RPCI from the Laboratory of Tumor Immunology and Biology, National Cancer Institute (NCI), National Institutes of Health (NIH), in Bethesda, MD, where he served as an Investigator. He has been honored by the NCI/NIH with five consecutive Performance Awards from 2003–2007, and was the recipient of six NIH Federal Technology Transfer Awards for the discovery of human T lymphocyte peptide epitopes reflecting ras codon 12 mutations. The identification of such mutated ras peptide sequences has also culminated in patent approval in both Europe and the U.S.Currently, Dr. Abrams serves on several external grant review panels. He has authored or co-authored more than 100 journal articles, reviews and book chapters, and has received numerous national and international invitations to speak.

Research Intrest

Defining molecular mechanisms by which lymphocytes kill tumor cells in vivo

List of Publications
Farren MR, Carlson LM, Netherby CS, Li P-K, Abrams SI, et al. (2014) Tumor induced STAT3 signaling impairs dendritic cell differentiation by downregulating PKC (beta) II expression. Sci. Signal. 7: ra16
Waight JD, Netherby C, Hensen ML, Miller A, Abrams SI , et al. (2013) Myeloid-derived suppressor cell development is regulated by a STAT/IRF-8 axis. J. Clin. Invest. 123: 4464-4478
Banik D, Khan ANH, Walseng E, Segal BH, Abrams SI (2012) Interferon regulatory factor-8 is important for histone deacetylase inhibitor-mediated antitumor activity. PLoS One 7: e45422