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Sadashiva S. Karnik

Staff
Molecular Cardiology
Cleveland Clinic Lerner Research Institute
United States of America

Professor Cardiology
Biography

Two transmembrane signaling receptors mediate the in vivo effects of the renin angiotensin system. Of these two, the Angiotensin II (AngII) type 1 receptor (AT1R) plays an indispensable role in physiological regulation of blood pressure and water-electrolyte balance. 

Research Intrest

GPCRs; Angiotensin Receptors; ARBs; Biased Signaling; Cardiac Hypertrophy; Hypertension; Heart Failure; Structure-function of GPCRs; Transmembrane Signaling; MicroRNA; Gene Expression; Chromatin Protein

List of Publications
Angiotensin Receptors: Structure, Function, Signaling and Clinical Applications. Singh KD, Karnik SS. J Cell Signal. 2016 Jun;1(2).
Significance of angiotensin 1-7 coupling with MAS1 receptor and other GPCRs to the renin-angiotensin system: IUPHAR Review 22. Karnik SS, Singh KD, Tirupula K, Unal H. Br J Pharmacol. 2017 May;174(9):737-753.
Experts in United States of America
Jairaj K. Acharya John Belote Wayde Brown Aimée M. Dudley Jon P Mochel Rabaa M. Al-Rousan Chancellor, Renate Karen Lee Abt Lin Li Hui-Hsien Chou Hamed I. Aly Cory K. Adams Mark Ehrensberger Jose Buitrago Gerhard J. Barone Jacquelyne Adams Jon Calabria Shelley Cannady Susan B. Adams Stoica George Daniel E. Acuna Tal Amasay Jason R. Wiles Matthew H Andersen Brian Rothman View More