Richard W. Fitch

Professor
Bioorganic/Medicinal Chemistry Pharmacognosy
Indiana State University
United States of America

Professor Biochemistry
Biography

B.S. 1992, Western Kentucky University Ph.D. 1998, University of Louisville Postdoctoral Experience: 1999-2003 National Institutes of Health

Research Intrest

Dr. Fitch is interested in the chemistry and pharmacology of natural products. Research in his laboratory is multifaceted, including isolation and structural characterization of novel biologically active compounds, as well as their synthesis and determination of their pharmacology. The purpose of this research is to discover compounds useful as pharmacologic probes and potential therapeutics for human disease. Medicinal chemistry is also used to this end, in that the compounds isolated from the natural source are lead compounds which can be chemically modified to tune their pharmacology, with the aim of developing selective drugs for treatment of disease with increased potency and efficacy, while reducing potential side effects.

List of Publications
Aachoui Y, Chowdhury RR, Fitch RW, Ghosh SK. Molecular signatures of phytol-derived immunostimulants in the context of chemokine–cytokine microenvironment and enhanced immune response. Cellular immunology. 2011 Dec 31;271(2):227-38.
Swaffar DS, Holley CJ, Fitch RW, Elkin KR, Zhang C, Sturgill JP, Menachery MD. Phytochemical investigation and in vitro cytotoxic evaluation of alkaloids from Abuta rufescens. Planta medica. 2012 Feb;78(03):230-2.
Turchi JJ, Fitch R, inventors; Indiana University Research, assignee. Small molecule inhibitors of replication protein A that also act synergistically with cisplatin. United States patent US 8,980,955. 2015 Mar 17.

Global Scientific Words in Biochemistry