Reza Salavati has a broad background in RNA biochemistry, molecular biology, and bioinformatics. He laid the groundwork for his research program by integrating computational and experimental approaches. His group developed methods to generate a comprehensive understanding of the mechanisms of gene regulation and protein-protein interaction network of trypanosomatid pathogens. He established a high throughput screen, identified potential inhibitors for RNA editing that kill T. brucei in vitro, and proposed the mechanism of inhibition. These are promising compounds which contribute to an exciting possibility for future drug development against these important pathogens.

1. Systems biology of trypanosomatid pathogens to identify key genes and pathways and determining their function 2. Post-transcriptional gene regulation and fundamental characterization of the RNA editing complex in trypanosomatid pathogens as a drug target The model organisms under study are three related trypanosomatid pathogens, together known as the Tritryps: Trypanosoma brucei group, T. cruzi , and Leishmania species. Respectively, these parasitic pathogens cause African sleeping sickness (and related diseases in animals), Chagas’ disease, and the spectrum of diseases called Leishmaniasis.