Assistant Professor
Department of Biology
Clarkson University
United States of America
I have always aimed to seek medical relevance in my research since my experience in human genetics and genetic counseling as a graduate student. I strongly believe in stem cells and induced pluripotent cells as the future of regenerative medicine, yet we first must understand how stem cells direct themselves to their final differentiated state within the complex setting of any tissue or organ. Deciphering the “communication with” and “education from” neighboring cells a stem cell and its progeny receives during the journey to a differentiated end point is the key to success in controlled re-differentiation of self-renewing cells for regenerative purposes. Using state of the art genomic technologies we have identified key aspects of the complex Gene Regulatory Network making up the axial skeleton (backbone) and the associated intervertebral discs (IVD). This equips us with a complex network of interactions at a gene regulatory level. Applying this knowledge to differentiate stem cells or patient derived induced pluripotent cells will allow for the development of safe alternatives to one of todays most common degenerative ailments, namely IVD degeneration.