Peter Tontonoz

Professor
Pathology and Laboratory Medicine
University of California los Angeles
United States of America

Professor Pathology
Biography

Dr. Tontonoz is Professor of Pathology and Laboratory Medicine. He received his B.A. from Wesleyan University and his M.D. and Ph.D. from Harvard Medical School. His Ph.D. thesis was carried out at the Dana-Farber Cancer Institute and his postdoctoral training at the Salk Institute for Biological Studies. He completed his residency training in Pathology at the University of California, San Diego. The focus of his laboratory is the control of gene expression by lipids and the role of nuclear receptors in lipid metabolism. His major research contributions include the delineation of role of PPAR and LXR in adipogenesis and atherosclerosis, and elucidation of mechanisms of crosstalk between metabolism, inflammation and immunity. He has been elected to the American Society of Clinical Investigation and the American Association of Physicians. 

Research Intrest

Dr. Tontonoz is the recipient of the Richard. E. Weitzman and Gerald D. Aurbach Awards from the Endocrine Society, the Jeffrey M. Hoeg Award for Basic Science and Clinical Research from the American Heart Association, and a Bristol Myers-Squibb Freedom to Discover Award in Cardiovascular Disease. He is a past President of American Society for Clinical Investigation. Dr. Tontonoz serves on a number of editorial boards and is a Reviewing Editor for eLife and the Editor in Chief of Molecular and Cellular Biology.

List of Publications
Sallam, T., Jones, M., Gilliland, T., Zhang, Li., Wu, X., Eskin, A., Sandhu, J., Casero, D., Vallim, T., Hong, C., Katz, M., Lee, R., Whitelegge, J., and Tontonoz, P. Feedback modulation of cholesterol metabolism by the lipid-responsive non-coding RNA LeXis, Nature, 2016; 534: 124-128.
Ito, A., Hong, C., Oka, K., Salazar, J.V., Diehl, C., Witztum, J.L., Diaz, M., Castrillo, A., Bensinger, S.V., Chan, L., and Tontonoz, P. Cholesterol accumulation in CD11c+ immune cells is a causal and targetable factor in autoimmune disease, Immunity, 2016; 45: 1311-1326.
Wang, J., Rajbhandari, P., Damianov, A., Waki, H., Ham, A., Sallam, T., Villanueva, C.J., Neilsen, R., Mandrup, S., Young, S.G., Reue, K., Saez, E., Whitelegge, J., Black, D.L., and Tontonoz, P. RNA binding protein PSPC1 promotes the differentiation-dependent nuclear export of adipocyte RNAs, J. Clin. Invest, 2017; 127: 987-1004.