Dr. McKeever received his undergraduate degree from Brown University, Providence, Rhode Island, his M.D. from the University of California, Davis in 1972, and his Ph.D. in Experimental Pathology from the University of South Carolina in 1976. After working at the National Institute of Health and a faculty appointment in the Department of Pathology, Uniformed Services, University Health Sciences, he came to the University of Michigan in 1983 as Associate Professor of Pathology. Dr. McKeever was promoted to the rank of Professor in 1999. He has served as the Chief of the Section of Neuropathology since 1983 and is the Director of the Neuropathology Residency. Dr. McKeever' s main clinical and research interests involve brain and pituitary tumors. Since 1995 and 1997, he has served on the Editorial Boards of the Journal of Neuro-Oncology and the Journal of Histochemistry and Cytochemistry, respectively. Since 1997, he has been editor of the Histochemical Society Newsletter. Dr. McKeever applies molecular markers to clinical and diagnostic problems in neuro-oncology and neuro pathology. For example, tumor progression in human gliomas is under study. At present it is not possible to determine which astrocytomas will rapidly progress to more malignant astrocytic gliomas and which will remain stable for years. Markers of cellular proliferation like MIB-1 nuclear antigen are being used on these gliomas to determine which markers will identify subsets of tumors of prognostic importance. Possible oncogenetic mechanisms of "hot spots" of cellular proliferation can be probe by in situ hybridization for chromosomal markers to determine whether cytogenetic abnormalities underly these proliferations. Tumor regression is associated with antigenic instability in gliomas, either as a result of growth of different cell populations, or of modulation of expression of the genome. Research activities have been directed towards understanding the basic biologic mechanisms of its antigenic instability.

 Brain tumors, pituitary tumors, neurotoxicity, and neuropathology.