Patrizia Casaccia

Professor
Neuroscience, Neurology and Genetics & Genomic Sciences
Icahn School of Medicine
United States of America

Professor Neurology
Biography

Dr. Patrizia Casaccia is Professor of Neuroscience, Genetics and Genomics; and Neurology. Dr. Casaccia is the Chief of the Center of Excellence for Myelin Repair at the Friedman Brain Institute at Mount Sinai School of Medicine. She received her medical degree with Honors from the University of Rome, and a PhD degree in Neurobiology from State University of New York (SUNY) Health and Science Center Brooklyn.  She then trained at Cornell Weill Medical Center in New York and at the Skirball Institute for Molecular Medicine at NYU. Dr. Casaccia’s work adopts molecular and cellular techniques to find new therapies for multiple sclerosis. Her work includes translational research in regenerative and personalized medicine.  The laboratory focuses on myelin repair with a special emphasis on the effect of aging and gender differences. In addition, her research addresses the mechanism of neuronal damage in patients with MS leading to novel screening for the discovery of new therapies to protect the neurons and replace damaged myelin.

Research Intrest

Aging, Axonal Growth and Degeneration, Cell Biology, Cell Cycle, Cellular Differentiation, Chromatin, Demyelination, Developmental Neurobiology, Epigenetics, Gene Regulation, Molecular Biology, Multiple Sclerosis, Myelination, Neuro-degeneration/protection, Neurobiology

List of Publications
Hernandez M, Patzig J, Mayoral SR, Costa KD, Chan JR, etal (2016) Mechanostimulation Promotes Nuclear and Epigenetic Changes in Oligodendrocytes. The Journal of neuroscience : the official journal of the Society for Neuroscience Vol: 36.
Douvaras P, Rusielewicz T, Kim KH, Haines JD, Casaccia P, etal (2016) Epigenetic Modulation of Human Induced Pluripotent Stem Cell Differentiation to Oligodendrocytes. International journal of molecular sciences Vol: 17.
Moyon S, Huynh JL, Dutta D, Zhang F, Ma D, etal (2016) Functional Characterization of DNA Methylation in the Oligodendrocyte Lineage. Cell reports.
Laitman BM, Asp L, Mariani JN, Zhang J, Liu J, Sawai S, etal (2016) The Transcriptional Activator Krüppel-like Factor-6 Is Required for CNS Myelination. PLoS biology Vol: 14.
Liu J, Moyon S, Hernandez M, Casaccia p (2016) Epigenetic control of oligodendrocyte development: adding new players to old keepers. Current opinion in neurobiology Vol: 39.