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Patricia K Sonsalla

Professor of Neurology
Toxicology
Environmental and Occupational Health Sciences Institute
United States of America

Professor Toxicology
Biography

Our research focuses on neurodegeneration, particularly as relates to Parkinson’s Disease (PD). Currently we are developing a progressive rat model of PD in which the neurotoxicant, 1-methyl-4-phenylpyridinium (MPP+), is chronically infused into the left cerebral ventricle via a cannula which is connected to an Alzet pump which delivers for 6 weeks. Using this model, we are investigating the role of microglia and other immune cells in mediating damage to the nigrostriatal dopaminergic neurons. Furthermore, we are studying the ability of drugs thought to modulate microglia function for their ability to rescue neurons after the process of neurodegeneration has been initiated

Research Intrest

Toxicology

List of Publications
Hossain, MM, Sonsalla, PK, Richardson, JR. Coordinated role of voltage-gated sodium channels and the Na+/H+ exchanger in sustaining microglial activation during inflammation. Toxicol. Appl. Pharmacol. 2013;273 (2):355-64. doi: 10.1016/j.taap.2013.09.011. PubMed PMID:24070585 PubMed Central PMC3874798
Sonsalla, PK, Coleman, C, Wong, LY, Harris, SL, Richardson, JR, Gadad, BS, Li, W, German, DC. The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism. Exp. Neurol. 2013;250 :376-83. doi: 10.1016/j.expneurol.2013.10.014. PubMed PMID:24184050 PubMed Central PMC3889207
Genestine, M, Lin, L, Durens, M, Yan, Y, Jiang, Y, Prem, S, Bailoor, K, Kelly, B, Sonsalla, PK, Matteson, PG et al.. Engrailed-2 (En2) deletion produces multiple neurodevelopmental defects in monoamine systems, forebrain structures and neurogenesis and behavior. Hum. Mol. Genet. 2015;24 (20):5805-27. doi: 10.1093/hmg/ddv301. PubMed PMID:26220976 PubMed Central PMC4581606
Brobey, RK, German, D, Sonsalla, PK, Gurnani, P, Pastor, J, Hsieh, CC, Papaconstantinou, J, Foster, PP, Kuro-o, M, Rosenblatt, KP et al.. Klotho Protects Dopaminergic Neuron Oxidant-Induced Degeneration by Modulating ASK1 and p38 MAPK Signaling Pathways. PLoS ONE. 2015;10 (10):e0139914. doi: 10.1371/journal.pone.0139914. PubMed PMID:26452228 PubMed Central PMC4599800
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