Biography

Associate Professor Horwood is the Principal Investigator of the Osteoimmunology Research group at The Kennedy Institute of Rheumatology, NDORMS, and University of Oxford She completed her PhD on osteoclast differentiation in 1999 at St Vincent’s Institute, University of Melbourne Research Interests: Osteoimmunology, Arthritis Honors & Awards: She was subsequently awarded the Victoria Premiers Commendation for Medical Research in 2000 as well as a Howard Florey fellowship from the Royal Society for postdoctoral studies at the Kennedy Institute, Imperial College London with Professor Sir Marc Feldmann and Professor Brian Foxwell She was appointed to a lectureship in 2004 and is now an associate professor with The University of Oxford She is currently a Senior Research Fellow of Arthritis Research UK Current research projects investigate links between bone cell function and multiple myeloma, inflammation and fracture repair, factors controlling osteoblast dedifferentiation, and mechanisms of new bone formation in ankylosing spondylitis and osteoarthritis

Research Intrest

Arthritis, Immunology

List of Publications
"Associate Professor Horwood is the Principal Investigator of the Osteoimmunology Research group at The Kennedy Institute of Rheumatology, NDORMS, and University of Oxford She completed her PhD on osteoclast differentiation in 1999 at St Vincent’s Institute, University of Melbourne Research Interests: Osteoimmunology, Arthritis Honors & Awards: She was subsequently awarded the Victoria Premiers Commendation for Medical Research in 2000 as well as a Howard Florey fellowship from the Royal Society for postdoctoral studies at the Kennedy Institute, Imperial College London with Professor Sir Marc Feldmann and Professor Brian Foxwell She was appointed to a lectureship in 2004 and is now an associate professor with The University of Oxford She is currently a Senior Research Fellow of Arthritis Research UK Current research projects investigate links between bone cell function and multiple myeloma, inflammation and fracture repair, factors controlling osteoblast dedifferentiation, and mechanisms of new bone formation in ankylosing spondylitis and osteoarthritis 1. Lymperi S, Ersek A, Ferraro F, Dazzi F, Horwood NJ Inhibition of osteoclast function reduces hematopoietic stem cell numbers in vivo Blood (2011) 117: 1540–1549 2. Ersek A, Santo AI, Vattakuzhi Y, George S, Clark AR, Horwood NJ Strain dependent differences in glucocorticoid-induced bone loss between C57BL/6J and CD-1 mice Sci Rep (2016) Vol 6 3. Horwood NJ m Macrophage Polarization and Bone Formation: A review Clin Rev Allergy Immunol (2016) 51: 79–86 4. Haslam SM, Roberts I, Dell A, Rahemtulla A, Horwood NJ, Karadimitris A, et al Glycosphingolipid synthesis inhibition limits osteoclast activation and myeloma bone disease J Clin Invest (2015) 125: 2279-2292 5. Chan JK, Glass GE, Ersek A, Freidin A, Williams GA, Gowers K, Espirito Santo AI, Jeffery R, Otto WR, Poulsom R, Feldmann M, Rankin SM, Horwood NJ, Nanchahal J. Low-dose TNF augments fracture healing in normal and osteoporotic bone by up-regulating the innate immune response. EMBO Mol Med (2015) 7: 547 – 561."