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Jon P Mochel Zhao Zhidong Mark Ehrensberger Limin Chen Jason R. Wiles Anirban Dutta Fakhri Al-Bagdadi Hermann Bragulla Jun Xia Levent Dirikolu Yun Wu Albert H. Titus Debanjan Sarkar Joseph Francis Hitesh Anantray Vyas Charles Lee Martha Littlefield Ciprian N. Ionita J. Michael Mathis Lei L. Ying View More
Melinda Faulkner

Assistant Professor
Biology
Bradley University
United States of America

Professor Biomedical Sciences
Biography

Dr. Faulkner studies how bacterial cells protect themselves against stressful conditions, in particular oxidative stress. Organisms that live in the presence of oxygen (including humans!) generate toxic oxygen-containing molecules such as hydrogen peroxide. Furthermore, our immune systems produce similar toxic oxygen species to combat bacterial infections. These reactive oxygen molecules damage enzymes and membranes, and may cause mutation or even cell death. Thus, the ability of cells, both microbial and human, to sense these damaging molecules and respond to them with an appropriate antioxidant defense is vital for their survival. In the laboratory, we are using molecular genetic techniques to investigate the enzymes and regulatory mechanisms used by bacteria to survive under conditions of oxidative stress.

Research Intrest

BIO, Life Sciences, Molecules to Cells, Biotechnology and Society, General Microbiology, Advanced Microbiology

List of Publications
Faulkner MJ, Ma Z, Fuangthong M, Helmann JD. Derepression of the Bacillus subtilis PerR peroxide stress response leads to iron deficiency. Journal of bacteriology. 2012 Mar 1;194(5):1226-35.
Lobstein J, Emrich CA, Jeans C, Faulkner M, Riggs P, Berkmen M. SHuffle, a novel Escherichia coli protein expression strain capable of correctly folding disulfide bonded proteins in its cytoplasm. Microbial cell factories. 2012 May 8;11(1):753.
Ma Z, Faulkner MJ, Helmann JD. Origins of specificity and cross‐talk in metal ion sensing by Bacillus subtilis Fur. Molecular microbiology. 2012 Dec 1;86(5):1144-55.
Experts in United States of America
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